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Metronidazole has shown proof of carcinogenic activity in scientific tests involving Long-term oral administration in mice and rats, but not in research involving hamsters.
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The following adverse reaction has been determined all through put up-acceptance usage of topical metronidazole. Mainly because this response is noted voluntarily from the population of uncertain measurement, It's not normally achievable to reliably estimate the frequency or set up a causal romantic relationship to drug publicity.
Unique experiments of metronidazole stages in human milk following intravaginally administered metronidazole haven't been performed. On the other hand, metronidazole is secreted in human milk in concentrations comparable to All those found in plasma adhering to oral administration of metronidazole.
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Fertility scientific studies are executed in mice up to 6 periods the recommended human oral dose (depending on mg/m2) and also have unveiled no evidence of impaired fertility.
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